Enhanced Dissolution of a Porous Carrier–Containing Ternary Amorphous Solid Dispersion System Prepared by a Hot Melt Method
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چکیده
منابع مشابه
Novel Patchouli Alcohol Ternary Solid Dispersion Pellets Prepared by Poloxamers
The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...
متن کاملNovel Patchouli Alcohol Ternary Solid Dispersion Pellets Prepared by Poloxamers
The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...
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This work studied artemether (ARTM) solid dispersion (SD) formulation using mixture of polymer excipient Soluplus, PEG 400, Lutrol F127, and Lutrol F68 melts at temperatures lower than the melting point of ARTM using a laboratory-size, single-screw rotating batch extruder. The effects of three surfactants PEG 400, Lutrol F127, and Lutrol F68 and parameters like mixing temperature, screw rotatin...
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In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and Hydroxypropyl Cellulose (HPC), at a drug loading of 10% w/w. Molecular modeling was used to determine the miscibility of the drug with the carrier polym...
متن کاملnovel patchouli alcohol ternary solid dispersion pellets prepared by poloxamers
the present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (pa) that can be used for the preparation of immediate release pellets formulation. two commercially available grades poloxamer 188 (p 188) and poloxamer 407 (p 407) were selected, and solid dispersions (sds) conta...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2018
ISSN: 0022-3549
DOI: 10.1016/j.xphs.2017.09.025